5/9/2025
Last update
5/9/2025
Reviewed By
Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
USERS' SCORE
Good
Based on 36 Reviews
8.2
Supplement Facts
Serving Size: 1 Veg Capsule
Amount Per Serving
%DV
Iron (elemental) (from 90 mg Ferrous Bisglycinate)(Ferrochel™)
18 mg
100%
Top Medical Research Studies
8
We examined how curcumin-mediated photodynamic therapy (CUR-PDT) induces a specific type of cell death called ferroptosis in fibroblast-like synoviocytes from rheumatoid arthritis patients.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Read More
7
We explored the impact of iron accumulation in multiple sclerosis (MS) lesions using advanced MRI techniques. Tracking 50 participants over an average of 3.3 years, we observed that iron deposits, identified as hyper-paramagnetic signals (HPS), closely linked with impaired remyelination and greater disability. Specifically, lesions with early signs of HPS showed a significant decline in myelin recovery compared to those without such deposits. These findings suggest that measuring iron levels could guide therapies aimed at enhancing myelin repair in MS patients.
Read More
8
Ferroportin regulates RA cell activity
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
Read More
Most Useful Reviews
9
Reduced hair loss
37 people found this helpful
Suffering from iron deficiency anaemia, I take iron supplements when I notice more hair than usual on my comb. This product has been effective, so I rate it five stars. It has no harsh effects on my digestive system, and next time, I plan to order an iron complex with vitamin C from the same manufacturer.
Read More
9
Effective for panic disorder
7 people found this helpful
I discovered that iron supplements alleviate my panic disorder. Since starting the treatment, my seizures have nearly vanished. Previously, I was anaemic and often felt light-headed, but that has improved. I initially took 36mg for six months and have since reduced the dosage to 18mg daily after dinner. I believe it's a worthwhile option for anyone suffering from panic disorder.
Read More
9
Improved sleep
7 people found this helpful
After using this supplement previously, I noticed my hair and nails looked healthier and younger. I hadn't used it for a while, but upon resuming, my sleep disorder improved immediately, and my day-night routine became normal. Iron deficiency had been the surprising cause all along!
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 3 Researches
7.7
- All Researches
8
Ferroportin regulates RA cell activity
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
Read More
8
We examined how curcumin-mediated photodynamic therapy (CUR-PDT) induces a specific type of cell death called ferroptosis in fibroblast-like synoviocytes from rheumatoid arthritis patients.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Read More
7
We explored the impact of iron accumulation in multiple sclerosis (MS) lesions using advanced MRI techniques. Tracking 50 participants over an average of 3.3 years, we observed that iron deposits, identified as hyper-paramagnetic signals (HPS), closely linked with impaired remyelination and greater disability. Specifically, lesions with early signs of HPS showed a significant decline in myelin recovery compared to those without such deposits. These findings suggest that measuring iron levels could guide therapies aimed at enhancing myelin repair in MS patients.
Read More
User Reviews
USERS' SCORE
Good
Based on 36 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Reduced hair loss
37 people found this helpful
Suffering from iron deficiency anaemia, I take iron supplements when I notice more hair than usual on my comb. This product has been effective, so I rate it five stars. It has no harsh effects on my digestive system, and next time, I plan to order an iron complex with vitamin C from the same manufacturer.
Read More
9
Effective for panic disorder
7 people found this helpful
I discovered that iron supplements alleviate my panic disorder. Since starting the treatment, my seizures have nearly vanished. Previously, I was anaemic and often felt light-headed, but that has improved. I initially took 36mg for six months and have since reduced the dosage to 18mg daily after dinner. I believe it's a worthwhile option for anyone suffering from panic disorder.
Read More
9
Improved sleep
7 people found this helpful
After using this supplement previously, I noticed my hair and nails looked healthier and younger. I hadn't used it for a while, but upon resuming, my sleep disorder improved immediately, and my day-night routine became normal. Iron deficiency had been the surprising cause all along!
Read More
9
Improved iron levels
6 people found this helpful
I have had anaemia since 2014, and I managed to raise my iron index from 62 to 128, which I'm immensely happy about. Previously, I took another type of Solgar iron, which only raised it to 118. When I wanted to reorder that, it was out of stock, so I opted for Now Foods. To my delight, my iron levels increased again! It's a great supplement.
Read More
9
Quality absorption
5 people found this helpful
If there are gastrointestinal issues, iron won't be absorbed properly, but if all is well and you need to replenish iron, these capsules are an excellent option. They absorb well without negative reactions, and there are no issues with stools or staining of teeth, unlike liquid iron supplements.
Read More
Frequently Asked Questions
7.5
Quick difference noticed
7 people found this helpful
A fantastic product that made a noticeable difference after just a few weeks. The quality and packaging are reliable. I'm very pleased with the swift delivery as well!
7.5
Effective iron supplement
7 people found this helpful
Initially, I felt terrible with low haemoglobin, which left me weak and dizzy. I decided to order iron, and it helped significantly! However, it is crucial to take it consistently for at least a month. Thank you for this effective product!
7.5
Effective during pregnancy
3 people found this helpful
This has been quite good! I've struggled with anaemia for a long time, especially during my pregnancy. This supplement truly helps, combating my drowsiness and dizziness. I keep ordering it as it genuinely works. My blood tests show improved levels! I'm very grateful for this product.
9
Dizziness reduced
1 people found this helpful
My 14-year-old daughter experienced periodic dizziness, which we attributed to low haemoglobin. After taking this supplement for about a month and a half, the effect was evident—the dizziness has notably diminished. It’s important to take it alongside vitamin C for better absorption. I’m reordering it for her to help regulate her periods.
9
Instant health improvement
I regularly order these for my husband, who suffers from iron deficiency. Once he starts taking these vitamins, his health improves immediately—his weakness and dizziness subside, indicating that his iron levels are rising! One jar lasts a while since he takes it in courses. The small capsule has a slight vegetable flavour, and I trust this brand for all our vitamin needs.
9
Effective for panic disorder
7 people found this helpful
I discovered that iron supplements alleviate my panic disorder. Since starting the treatment, my seizures have nearly vanished. Previously, I was anaemic and often felt light-headed, but that has improved. I initially took 36mg for six months and have since reduced the dosage to 18mg daily after dinner. I believe it's a worthwhile option for anyone suffering from panic disorder.
9
Improved sleep
7 people found this helpful
After using this supplement previously, I noticed my hair and nails looked healthier and younger. I hadn't used it for a while, but upon resuming, my sleep disorder improved immediately, and my day-night routine became normal. Iron deficiency had been the surprising cause all along!
7.5
No side effects
3 people found this helpful
The chelated form of iron absorbs well without side effects! I find most drugs contain iron sulfate, which causes discomfort. I regularly check my ferritin levels and take iron if necessary, ensuring I also have B vitamins and vitamin C, as they aid absorption.
9
Hair improvement
11 people found this helpful
For the first time, I felt a quick effect. I ordered this along with folic acid and vitamins C and B12, and after two weeks my hair became soft, and I noticed new growth. I’m very pleased with this outcome!
9
Improved haemoglobin levels
3 people found this helpful
For a long time, I struggled with low haemoglobin. Following various treatments with little effect, I ordered this product and saw significant improvement. Initially, taking 36mg wasn't effective; however, I switched to 18mg, which improved digestibility. Now, my haemoglobin is stable at 140!
9
Improves state of health
2 people found this helpful
Having latent anaemia, I take iron every month for 10 days. It quickly improves my iron levels, and I feel it reflected in my health and blood tests. I plan to increase the dosage next time!
8
Ferroportin regulates RA cell activity
We aimed to understand how iron affects autoimmune disorders, specifically focusing on rheumatoid arthritis (RA). Our study explored the function of ferroportin (FPN), a membrane iron transporter, in the proliferation and movement of fibroblast-like synoviocytes (FLS) linked to RA.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
We found that FPN levels were significantly lower in RA tissues compared to normal tissues, hinting at a potential connection between iron metabolism and the disease. By conducting a series of assays, we demonstrated that increased FPN expression leads to a slowdown in FLS growth and migration. This effect seems to be mediated through the suppression of the PI3K/AKT signaling pathway and is accompanied by elevated levels of reactive oxygen species (ROS).
These findings suggest that ferroportin might play a crucial role in the development of RA by regulating iron levels in FLS. This insight opens new avenues for potential treatments targeting iron dysregulation to help alleviate joint damage in RA patients.
8
We examined how curcumin-mediated photodynamic therapy (CUR-PDT) induces a specific type of cell death called ferroptosis in fibroblast-like synoviocytes from rheumatoid arthritis patients.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
Using a rat model, we monitored joint swelling and inflammation while analyzing key proteins involved in this process. The results indicated that CUR-PDT successfully reduces harmful cell growth and inflammation in RA cells by targeting the Nrf2-xCT-GPX4 pathway.
This finding emphasizes the potential of CUR-PDT as a treatment strategy in managing rheumatoid arthritis.
7
We explored the impact of iron accumulation in multiple sclerosis (MS) lesions using advanced MRI techniques. Tracking 50 participants over an average of 3.3 years, we observed that iron deposits, identified as hyper-paramagnetic signals (HPS), closely linked with impaired remyelination and greater disability. Specifically, lesions with early signs of HPS showed a significant decline in myelin recovery compared to those without such deposits. These findings suggest that measuring iron levels could guide therapies aimed at enhancing myelin repair in MS patients.
References
- Shao W, Liu F, Zhu L, Qian W, Meng Q, et al. Ferroportin inhibits the proliferation and migration of fibroblast-like synoviocytes in rheumatoid arthritis via regulating ROS/PI3K/AKT signaling pathway. Eur J Pharmacol. 2025;987:177205. 10.1016/j.ejphar.2024.177205
- Sun L, Niu Y, Liao B, Liu L, Peng Y, et al. CUR-PDT induces ferroptosis of RA-FLS via the Nrf2/xCT/GPX4 pathway to inhibit proliferation in rheumatoid arthritis. Inflamm Res. 2025;74:53. 10.1007/s00011-025-02019-2
- Shin HG, Kim W, Lee JH, Lee HS, Nam Y, et al. Association of iron deposition in MS lesion with remyelination capacity using susceptibility source separation MRI. Neuroimage Clin. 2025;45:103748. 10.1016/j.nicl.2025.103748
